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  Health News Update Effective Fat Hormone Control Key Natural Nutrient For Cardiovascular Health, Diabetes and Weight Management According To Research The potential health benefits of resveratrol may be due to is ability to activate the powerful fat controlling hormone adiponectin, according to an important new study. Researchers from the University of Texas found that the antioxidant compound resveratrol stimulates the expression of adiponectin, a hormone released from fat cells, which plays an important role in the regulation of insulin sensitivityand energy. The new study, published in the Journal of Biological Chemistry, reports that resveratrol stimulates the expression and protein clustering (multi-merization) of adiponectin in specialized fat cells through the activation of a protein known as disulfide bond-A oxidoreductase- like protein (DsbA-L). "Our study uncovers a novel mechanism by which resveratrol exerts its health beneficial effect," said pharmacology researchers at University of Texas. "The results from these studies should be of interest to those who are obese, diabetic and growing older," he added. They said the finding that resveratrol promotes adiponectin expression provides a novel mechanism by which resveratrol exerts its health beneficial functions. Resveratrol, a powerful polyphenol and anti-fungal chemical, is regarded as the major bioactive compound in grapes, grape seeds and red wine. It has long been associated with the so-called "French Paradox" which describes the low incidence of heart disease and obesity among the French, despite their relatively high-fat diet and levels of wine consumption. Interest in the compound exploded in 2003 when research from from Harvard reported that resveratrol was able to increase the lifespan of yeast cells. The research, published in Nature, was greeted with international media attention and stimulated hope worldwide for an effective anti-aging pill. According to the Harvard study's findings, resveratrol activated a gene called sirtuin1 (Sirt1), which is also activated during calorie restriction in various species, including humans. However, recent studies have suggested that resveratrol may exert its beneficial functions via Sirt1-independent mechanisms. Adiponectin has a wide range of beneficial effects on obesity- related medical complications, and noted that both adiponectin and resveratrol display anti-obesity, anti-insulin resistance and anti-aging properties. Whilst recent research has identified that the expression DsbA-L, a protein that is known to regulate the expression of adiponectin, is significantly reduced in obese human subjects and mice.